Effect of malondialdehyde on deformability of human umbilical vein endothelial cells
Kakorin, I.D.; Antonova, O.A.; Balashov, S.A.; Mel'kumiants, A.M.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 96(2): 147-153
2010
ISSN/ISBN: 0869-8139 PMID: 20432722 Document Number: 646659
In experiments on cultured endothelial cells of human umbilical vein, we found that incubation of these cells during 24 hours with malondiaidehyde (cone. 200 microM) led to over two-fold increase in the cell stiffness. These data suggest that manifold augmentation of malondialdehyde concentration during oxidative stress may be accompanied by a considerable weakening of endothelium-dependent shear stress-induced arterial dilation.
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