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Genetic analyses of HIV-1 pol sequences from Zimbabwean patients

Falasca, F.; Temperoni, C.; Mazzuti, L.; Lo Presti, A.; Ciccozzi, M.; Di Filippo, E.; Iaiani, G.; Taliani, G.; Turriziani, O.

New Microbiologica 37(3): 377-381

2014

ISSN/ISBN: 1121-7138
PMID: 25180853
Document Number: 674943
This study analysed the sequence of HIV-1 pol gene derived from Zimbabwean infected patients. Sequence analysis, performed on 8 samples, revealed that sequences were classified as subtype C (n=5), subtype B (n=2) and CRF01_AE (n=1). Two patients, treated with a therapeutic regimen containing NRTI/NNRTI, harboured drug resistance mutations in HIV-1 DNA. Phylogenetic analysis performed on subtype C sequences showed that our strains were aggregated in different clusters depending on the country of origin.

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