Genetic analyses of differences in incidence of mammary tumors and reticulum cell neoplasms with the use of recombinant inbred lines of mice
Dux, A.; Mühlbock, O.; Bailey, D.W.
Journal of the National Cancer Institute 61(4): 1125-1129
1978
ISSN/ISBN: 0027-8874 PMID: 212568 Document Number: 125333
The influence of genes in addition to those in the H-2 at 3 mo. of age and were force bred. They were observed for mammary tumors. The B6 strain was least susceptible and mammary tumors appeared late in life. The BALB/c strain was most susceptible and the tumors appeared early in life. The course of tumor development in the RI lines fell between these extremes. The RI strain distribution pattern of mammary tumor incidence indicated that at least 1 and probably several loci in addition to those at H-2 determined the difference between the BALB/c and B6 strains. Effects of the other gene(s) appeared to be even more important than those of H-2. The locations of those loci were clear. The spontaneous incidence of reticulum cell neoplasms was also recorded. The most frequently formed neoplasm of the reticular system was a Hodgkin's-like lesion. An influence of the H-2 complex is suggested.