Genetic studies in NZB mice. VI. Association of autoimmune traits in recombinant inbred lines
Miller, M.L.; Raveche, E.S.; Laskin, C.A.; Klinman, D.M.; Steinberg, A.D.
Journal of Immunology 133(3): 1325-1331
1984
ISSN/ISBN: 0022-1767 PMID: 6086755 Document Number: 222214
Because recombinant inbred lines can have any combination of parental genes, the numbers and the association of genes responsible for traits can be approximated by examining phenotypic distribution in these lines. The studies reported uncovered 2 major families of non-linked genetic loci whose interactions underlie autoimmune abnormalities in NZB mice. One family of genes leads to antibodies to murine leukaemia virus, ssDNA and erythrocytes, as well as to defective tolerance to bovine gamma -globulin. The other group of genes leads to polyclonal B-cell activation, stem-cell abnormalities, endogenous murine leukaemia virus expression, and naturally occurring thymocytotoxic autoantibodies. These results explain previously observed dissociation between the traits associated with these 2 groups of genes. [For Pt. V see ABA 49, 5984].