Modification of the genetic effect of N-nitrosoethylurea in inbred mice by para-aminobenzoic acid
Malashenko, A.M.; Vasil'eva, S.V.
Genetika 21(4): 582-585
1985
ISSN/ISBN: 0016-6758 PMID: 3924730 Document Number: 252938
The ability of para-aminobenzoic acid--vitamin (PABA) to influence the sensitivity of mice to alkylating mutagens was studied. PABA had no influence on the cytogenetic effect of thio-TEPA. It was determined that PABA altered the effect of N-ethyl nitrosourea (ENU). The direction of modification depends on animal genotype: pre-treatment with PABA decreases the frequency of chromosome aberrations in bone marrow cells of CBA/LacY and C57BL/JY mice, but significantly increases it in 101/HY mice. The PABA influence on the frequency of gene mutations induced by ENU in melanocytes of mice and revealed by "spot-test" was not determined.