Codon optimization of hemagglutinin as a promising tool for improving of the influenza vaccines immunogenicity
Fedorova, E.F.; Kiseleva, I.V.; Auewarakul, P.; Suptawiwat, O.; Rudenko, L.G.
Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 4: 3-9
2014
ISSN/ISBN: 0208-0613 PMID: 25845134 Document Number: 672385
Modification of the codon bias of sequences is a promising tool of the gene expression control. The theoretical basis of the codon optimization is reviewed, data on experiments in changing the viral gene codon bias for purposes of vaccine development are discussed. Research into the field of the influenza vaccine immunogenicity improvement with codon optimization method is reviewed. Prospects of the use of the codon optimization technique for influenza vaccine development are considered.