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Immunogenic activity of the viral hemagglutinin and neuraminidase from live and inactivated influenza vaccines

Kustikova, I.G.; Gagarinova, V.M.; Gorev, N.E.; Shadrin, A.S.

Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 4: 79-84

1983

ISSN/ISBN: 0372-9311
PMID: 6868890
Document Number: 211173
Paired sera from 600 persons immunized with live or inactivated influenza vaccines have been studied in the hemagglutination inhibition (HAI) and influenza virus elution inhibition (EI) tests. The possibility of using, in principle, the EI test for the evaluation of the immunogenicity of the vaccine has been shown. The time course of antibody formation has been found to correlate with both hemagglutinin and neuraminidase of influenza virus. To evaluate the immunogenicity of influenza vaccines with greater precision, taking into account not only seroconversions routinely revealed in the HAI test, but also seroconversions registered only in the EI test is recommended.

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