Effects of omega-3 polyunsaturated fatty acids on antioxidant capacity in rats
Kravchenko, L.V.; Aksenov, I.V.; Avren'eva, L.I.; Beketova, N.A.; Trusov, N.V.; Guseva, G.V.
Voprosy Pitaniia 82(2): 4-9
2013
ISSN/ISBN: 0042-8833 PMID: 24000693 Document Number: 665151
Dietary administration of omega-3 polyunsaturated fatty acids (EPA + DHA, 1,2:1) at dose 0.3 or 1 g/kg bw during 4 weeks led to minor (by 14% and 17%, p<0.05) decrease of serum antioxidant capacity and serum level of vitamin E (by 30% and 31%, p<0.05) and the activity of paraoxonase-1 (by 14% at 0.3 g/kg bw, p<0.05). The activity of antioxidant enzymes in liver increased in a dose-dependent manner. At higher dose of omega-3 polyunsaturated fatty acids a 45% increase in the activity of paraoxonase-1 (p<0.05), 21% -heme oxygenase-1 (p>0.05), 68% - quinone reductase (p<0.05), 19% - glutathione S-transferase (p<0.05) compared to the control group was found. The direct relationship between activities of enzymes and increase of MDA level in liver (by 47 and 107%, p