The phenotype IFNy+cd69- of T-lymphocytes of umbilical blood associated with epidemiologically verified risk factors of atopy formation
Tereshchenko, S.I.; Babushkin, V.A.; Ol'khovskiĭ, I.A.; Novitskiĭ, I.A.; Isakov, I.V.; Shakina, N.A.
Klinicheskaia Laboratornaia Diagnostika 6: 50-52
2012
ISSN/ISBN: 0869-2084 PMID: 22946227 Document Number: 663836
The article deals with the determination of possible role of imbalance of lymphocytes TH1/TH2 at birth in pathogenesis of atopy development in children. The subpopulation compound of umbilical blood lymphocytes was examined on sampling of 153 newborns. The following prospective monitoring was applied during first year of life. It is established that the low content ofnonactivated mononuclears in umbilical blood producing gamma-interferon (IFNy+/CD69-) is associated with atopic family anamnesis (p = 0.006), residing of pregnant woman in town (in comparison with rural area, p = 0.02) and male gender of newborn in case of repeated labor (p = 0.008). This situation matches the epidemiologic verified risk factors of atopy formation in children. The contact of pregnant woman with domestic pets results in increasing of content of activated lymphocytes producing gamma-interferon (IFNy+/CD69-), p = 0.03. The decrease of content of nonactivated cells producing gamma-interferon (IFNy+/CD69-) is a strong and independent predictor of formation of atopic dermatitis in children of infancy age. The relative risk of formation of atopic dermatitis consisted 3.4 (1.19-9.69).