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Role of serum factors in decreasing the reaction of peripheral blood lymphocytes in schizophrenia to PHA stimulation

Babaian, N.G.; Lideman, R.R.; Lozovskii, D.V.; Prilipko, L.L.; Faktor, M.I.

Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 78(1): 80-86

1978

ISSN/ISBN: 0044-4588
PMID: 75627
Document Number: 127898
The blood serum of schizophrenic patients and three of its studied fractions (gamma-globulins and remaining after elimination of gamma-globulins and ultrafiltrate protein fractions) inhibit the lymphocyte response of normals to PHA stimulation (an increase of the DNA content in cells). An insignificant inhibitor effect in the blood serum of normals was seen only in the protein fraction. The PHA precipitating activity of the blood serum in schizophrenic patients which is mainly connected with its protein fraction is increased by 30%. However, there are no correlations between this blood serum activity and its capability to inhibit the response of lymphocytes to PHA stimulation.

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