Composition and role of short chain fatty acids in feces and peripheral blood serum of patients with cholelithiasis
Minushkin, O.N.; Prikhno, N.I.; Ardatskaia, M.D.; Maslovskiĭ, L.V.; Ikonnikov, N.S.
Klinicheskaia Meditsina 79(4): 37-39
2001
ISSN/ISBN: 0023-2149 PMID: 11496737 Document Number: 529124
Gas-liquid chromatography was used to estimate content of short-chain fatty acids (SCFA) in 25 patients with cholelithiasis, 32 patients with irritable colon syndrome and constipation (ICS) and 35 healthy subjects. It was found that SCFA absolute and relative concentration in the feces of cholelithiasis patients is abnormal indicating disturbance of microbiocenosis as shown by changes in functional activity of some anaerobes of the intestinal microflora participating in enterohepatic circulation of bile acids. Alterations of SCFA content in the serum of cholelithiasis patients may be related to steroids disbolism. The study of SCFA in the feces and peripheral blood serum from cholelithiasis patients is of diagnostic value.