Umbilical cord blood transplant from HLA-mismatched unrelated donor in high-risk leukemia
Arcese, W.; Iori, A.P.; Screnci, M.; Guglielmi, C.; Mengarelli, A.; Carmini, D.; Testi, A.M.; Moleti, M.L.; Cimino, G.; Perrone, P.; Laurenti, L.; Elia, L.; Boecklin, F.; Romano, A.; De Felice, L.; Mandelli, F.
Bone Marrow Transplantation 21(Suppl 3): S85-S86
1998
ISSN/ISBN: 0268-3369 PMID: 9712504 Document Number: 488531
Twelve consecutive children with high-risk leukemia have been submitted to UCB transplant from unrelated 1 or 2 loci HLA-mismatched donor. All patients received an identical regimen for conditioning and GVHD prophylaxis. The median dose of viable nucleated cells infused was 2.8 x 10(7)/kg bw (range 1.4-7.9). Of 11 patients evaluable for engraftment, the hematopoiesis was of full donor origin in seven patients and autologous in four. The probability of disease-free survival at 1 and 2 years from UCB transplant is 60 and 42%, respectively.