Coumarins from Skimmia arborescens and its anti-inflammatory effect
He, L.; Yang, S.; Wu, D.; Cui, T.; Wei, D.; Ding, Z.
Zhongguo Zhong Yao Za Zhi 37(6): 811-813
2012
ISSN/ISBN: 1001-5302 PMID: 22715728 Document Number: 663829
To investigate chemical constituents contained in Skimmia arborescens. The chemical constituents were separated by silica gel column chromatography, pharmadex LH-20, RP-C18, and 1H, 13C-NMR spectroscopic analysis were employed for the structural elucidation. Six coumarin compounds were separated from S. arborescens. Their structures were elucidated as umbelliferone (1), scopoletin (2), scopolin (3), nodakenetin (4), skimmin (5), 6, 7-dimethoxycoumarin (6), and all compounds were separated from the plant for the first time. Using the model of ear swelling caused by xylol of mice, the anti-inflammatory effect of its total extract was evaluated. The result indicated that middle and high dose groups of its total extract could obviously inhibit the ear swelling caused by xylol of mice.