Ammonium bituminosulfonate (Ichthyol) . Anti-inflammatory effect and inhibition of the 5-lipoxygenase enzyme
Diezel, W.; Schewe, T.; Rohde, E.; Rosenbach, T.; Czarnetzki, B.M.
Der Hautarzt; Zeitschrift für Dermatologie Venerologie und verwandte Gebiete 43(12): 772-774
1992
ISSN/ISBN: 0017-8470 PMID: 1361926 Document Number: 390087
Ammonium bituminosulphonate (Ichthyol) inhibits 5-lipoxygenase activity in human polymorphonuclear neutrophils. The inhibition is dose-dependent and occurs at non-cytotoxic concentrations of the drug. This results in a decreased release of Leukotriene B4 from polymorphonuclear neutrophils. Furthermore, when applied to the ear skin of AB/Bln mice pretreated with croton oil, Ichthyol reduces the inflammatory reaction.