Effects of capsaicin on oxidative modification of blood plasma proteins and arterial blood pressure in fructose-fed rats
Tolochko, Z.S.; Spiridonov, V.K.
Eksperimental'naia i Klinicheskaia Farmakologiia 75(3): 3-6
2012
ISSN/ISBN: 0869-2092 PMID: 22679744 Document Number: 662560
The influence of the activation of capsaicin-sensitive nerves with capsaicin on the oxidative modification of blood plasma proteins and arterial blood pressure was studied in Wistar rats fed with 12.5% fructose in drinking water for 10 weeks. The obtained results indicate that fructose feeding induces an increase in the arterial blood pressure and the content of plasma blood protein carbonyl derivates. At the same time, in hypertensive rats, the stimulation of sensory nerves by capsaicin (1 mg/kg, i.p.) decreases the content of oxidized proteins in the plasma and normalizes the arterial blood pressure. It is suggested that capsaicin-sensitive nerves are involved in the regulation of oxidative destruction of proteins as well as in blood pressure control under metabolic disturbances produced by prolonged fructose feeding.