Effect of atrial natriuretic factor on arterial blood pressure and frequency of heart contraction in rats with genetically determined hypertension and in normotensive rats
Lapiński, M.; Stepniakowski, K.; Januszewicz, A.; Noszczyk, B.; Szczepańska-Sadowska, E.
Polski Tygodnik Lekarski 44(12-13): 285-288
1989
ISSN/ISBN: 0032-3756 PMID: 2530501 Document Number: 338594
An effect of peptide released by the heart atria of mammals and called the atrial natriuretic factor (ANF) on blood pressure and heart contractions was studied in rats with genetically determined arterial hypertension (SHR) and in normotensive Wistar-Kyoto rats (WKY). Nine male SHR rats and 11 male WKY rats, aged between 12 and 16 weeks, were given normal saline infusion for 30 minutes through implanted catheters to both ulnar vein and artery. Then, an infusion of ANF at the rate of 0.3 microgram/kg per hour followed for 35 minutes. An infusion of ANF produces significant decrease in the mean arterial blood pressure, systolic and diastolic pressures without significant effect on pulse pressure and heart contractions. AFN infusion with the same rate did not produce any significant differences in the arterial blood pressure and heart contractions in Wistar-Kyoto rats. The obtained results suggest that ANF may play a role in pathogenesis of the arterial blood hypertension.