In vitro study of delta 6- and delta 5-desaturations of linoleic and dihomo-gamma-linolenic acids during the development of arterial hypertension as a function of age in spontaneously hypertensive rats (SHR) as compared to normotensive rats (WKY)
Narce, M.; Poisson, J.P.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 178(4): 458-466
1984
ISSN/ISBN: 0037-9026 PMID: 6241017 Document Number: 225537
delta 6- and delta 5-desaturations of linoleic [1(14)C] or dihomo-gamma-linolenic [2(14)C] acids are partially inhibited, in vitro, in liver microsomes of spontaneously hypertensive rats (SHR) comparatively to normotensive rats (WKY). The inhibition is more light when the animals are young and the blood hypertension not well established. These results are particularly important, for these desaturations are fundamental steps in the biosynthesis of prostaglandins precursors, prostaglandins and their original fatty acids being involved in blood pressure regulation.