The effects of Ca++ antagonistic drug, verapamil, on heart rate, arterial blood pressure, ECG, and blood catecholamine concentration during neuroleptanesthesia
Nishimoto, T.; Shibata, O.; Haseba, S.; Goto, Y.; Hagiwara, M.
Masui. Japanese Journal of Anesthesiology 30(12): 1310-1316
1981
ISSN/ISBN: 0021-4892 PMID: 7346646 Document Number: 175623
Verapamil, a Ca2+ antagonistic drug, is used for the treatment of angina pectoris, arrhythmias and hypertension. This drug reduces the arterial blood pressure mainly by dilating the peripheral vessels, but it also has a negative inotropic action. The hemodynamic effects of verapamil were studied in dogs anesthetized with halothane, N2O and O2 (GOF) and in men under neuroleptanesthesia (NLA). Verapamil 0.1 mg/kg or 0.2 mg/kg administered i.v. in 12 dogs anesthetized with GOF exhibited significant effects on heart rate (10-20%), systolic pressure (25-30%), diastolic pressure (35-40%), maximum dp/dt (20%) and renal blood flow (20-30%). There was no significant change in cardiac output. Verapamil 0.1 mg/kg i.v. in 15 men under NLA decreased systolic pressure to 71% and diastolic pressure to 75% at 2 min after administration; blood pressure then recovered gradually. Heart rate and blood epinephrine concentration were unchanged. Blood norepinephrine concentration increased at 2 min after administration, but there was no statistically significant difference. Evidently verapamil decreases blood pressure safely during NLA.