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Relationships between blood pressure, heart rate and plasma epinephrine, norepinephrine, angiotensin II concentrations, plasma renin activity during chronic guanfacine therapy in patients with essential arterial hypertension

Collart, F.; Staroukine, M.; Verniory, A.

Acta Cardiologica 40(3): 269-276

1985

ISSN/ISBN: 0001-5385
PMID: 3895792
Document Number: 242613
The evolution of blood pressure, heart rate, epinephrine, norepinephrine, angiotensin II and plasma renin activity was studied in 10 patients with essential arterial hypertension before and during a 2 mo. period of treatment with guanfacine, a new centrally acting hypotensive drug. Guanfacine was proven effective in lowering both systolic and diastolic supine and standing blood pressure. A decrease in supine and standing norepinephrine plasma concentrations and plasma renin activity was observed. No change was seen in epinephrine or angiotensin II. The fall in supine blood pressure observed during the treatment period was positively correlated with the change in norepinephrine.

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