Experimental nephrolithiasis: nephroprotective effect of calcium antagonists
Bat'ko, A.B.; Oseshniuk, R.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 75(12): 25-26
2012
ISSN/ISBN: 0869-2092 PMID: 23700664 Document Number: 661396
Increasing intracellular calcium ion concentration in the cytoplasm is the starting point in the activation of cell death. Regulation of these pathological processes in various organs and tissues is possible using agents from the group of calcium antagonists. This study was aimed at assessing the level of urinary excretion of two enzymes, lactate dehydrogenase (LDH, EC 1.1.1.27) and y-glutamyltransferase (GGT, EC 2.3.2.2), calcium antagonists in an experimental model of nephrolithiasis and finding ways to pharmacological protection of the kidneys. It established that the use of calcium antagonists can reduce the excretion of LDH by 20% and the excretion of GGT by more than 40%.