Calcium antagonists in hypertensive disease: experimental evidence for a new therapeutic concept
Kazda, S.; Garthoff, B.; Luckhaus, G.
Postgraduate Medical Journal 59(Suppl 2): 78-83
1983
ISSN/ISBN: 0032-5473 PMID: 6351044 Document Number: 203720
In animal experiments calcium antagonist drugs decrease peripheral vascular resistance, improve renal sodium excretion and thus, diminishing the volume load, reduce cardiac hypertrophy. In experimental malignant hypertension these drugs preserve tissue integrity by inhibiting the deleterious calcium overload of vessels.