Effect of calcium antagonists on the Ca2 (+) paradox
Tribulová, N.; Slezák, J.; Ravingerová, T.; Okruhlicová, L.
Bratislavske Lekarske Listy 91(6): 437-445
1990
ISSN/ISBN: 0006-9248 PMID: 2393826 Document Number: 367048
The model of calcium paradox was used to test the effect of the calcium entry blocker Diltiazem (concentration 4.0 mumol.l-1) and of the calmodulin inhibitor Trifluoroperazin (concentration 1.0 mumol.l-1). Application of each preparation resulted in improved cardiac function manifested by restoration of the electrical and contractile activity and by increased coronary flow. Both Diltiazem and Trifluoroperazin exerted a protective effect on the preservation of enzymatic activities and of ultrastructure in conditions of impaired calcium homeostasis.