Enhancement of hepatic tumors induced by N-nitrosodimethylamine in female toads Bufo regularis by oestrone
Sakr, S.A.; el-Mofty, M.M.; Mohamed, A.M.
Archiv für Geschwulstforschung 59(1): 7-10
1989
ISSN/ISBN: 0003-911X PMID: 2923526 Document Number: 660
The effect of oestrone on hepatic tumours induced in the female toads Bufo regularis by N-nitrosodimethylamine (DMNA) was evaluated. Injecting the toads with DMNA induced hepatocellular carcinomas in 17% comparable with 23% in toads injected with DMNA plus oestrone. These results show that oestrone insignificantly enhanced the tumour formation. Oestrone alone induced hepatic tumours in only 4 cases and was considered as a weak initiator.
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