Comparative study of remaxol and ademethionine effects on reparative regeneration processes in the liver subjected to surgical intervention
Vinogradova, T.I.; Sukhanov, D.S.; Zabolotnykh, N.V.; Kovalenko, A.L.; Vasil'eva, S.N.; Romantsov, M.G.
Eksperimental'naia i Klinicheskaia Farmakologiia 74(2): 34-38
2011
ISSN/ISBN: 0869-2092 PMID: 21476284 Document Number: 652755
The influence of remaxol, reamberin and ademethionine on the process of reparative regeneration in the liver was experimentally studied in a group of 100 white male rats subjected to partial hepatectomy in comparison with intact and drug-untreated operated control animals. The administration of remaxol and ademethionine favored more intensive and early accumulation of the regenerated liver weight, restoration of the general structure of the liver, and appearance of the signs of reparative regeneration. Only rats treated with ademethionine exhibited clearly pronounced enhanced alterative processes in the liver. A morphometric investigation showed that remaxol and ademethionine improved the quality of a current compensatory process and stimulated intracellular regeneration reactions. Under the conditions of remaxol administration, the most pronounced effect of liver regeneration was observed on the 4th day after operation, while in the case of ademethionine the maximum effect was observed on the 10th day.