Reparative regeneration of the liver as a model for the preclinical study of the hepatotropism of anti-alcohol agents
Liubimov, B.I.; Iavorskiĭ, A.N.; Sorokina, A.V.
Farmakologiia i Toksikologiia 48(1): 87-92
1985
ISSN/ISBN: 0014-8318 PMID: 3979545 Document Number: 244084
It has been established that administration of teturam (200 mg/kg) per os once a day for 14 days retards reparative regeneration of the liver in rats following partial hepatectomy and exerts an additional damaging action on the population of regenerating hepatocytes. Administration of potassium orotate (100 mg/kg) per os once a day for 14 days speeds up, on the contrary, organ regeneration. The combined use of the drugs potentiates paradoxically the negative hepatotropic effect of teturam. It is concluded that experimental reparative regeneration of the rat liver can be applied to the assessment of hepatotropism of the antialcoholic drugs.