The hepatotropic activity of runihol and ademethionine against experimental liver damage caused by first-line antituberculosis drugs
Sukhanov, D.S.; Vinogradova, T.I.; Zabolotnykh, N.V.; Vitovskaia, M.L.; Kovalenko, A.L.
Arkhiv Patologii 76(2): 26-30
2014
ISSN/ISBN: 0004-1955 PMID: 25051722 Document Number: 673864
Experiments on 62 male albino outbred rats investigated the impact of 14-day use of the oral hepatotropic agents ademethionine and runihol in different doses in liver damage caused by a antituberculosis combination (HRZ). HRZ-induced liver damage was shown to be accompanied by the development of cytolysis and cholestasis. The test drugs in the doses under study had a mixed effect, by reducing the magnitude of biochemical manifestations of these syndromes. Both drugs favored the recovery of the structure of the liver and the reduction of the extent of carbohydrate, protein, and fat dystrophies of the organ. As in previous investigations, ademethionine was found to have enhanced activity of alterative processes in the liver.