Deficit of polyunsaturated fatty acids in patients with celiac disease
Krums, L.M.
Eksperimental'naia i Klinicheskaia Gastroenterologiia 3: 31-34
2011
ISSN/ISBN: 1682-8658 PMID: 21695950 Document Number: 649843
The aim--to study fatty acid composition of lipids in blood serum of patients with celiac disease, their role in metabolic processes and methods of therapy. The study included 28 patients with celiac disease with malabsorption syndrome III degree: 20 women and 8 men aged 17 to 45 years. Was determined: steatorrhea with help of chemical quantitative method of Van de Kamer, fatty acids in blood serum lipids by thin layer and gas chromatography. There was a substantial steatorrhea in patients with celiac disease with malabsorption syndrome III in severity. Most patients with celiac disease were found to decrease the essential fatty acids, the most significant--arachidonic acid, which leads to disruption of the synthesis of prostaglandins, prostacyclin, a tendency to thrombosis. Parenteral administration of the drug essentiale helps normalize the fatty acid composition of serum.