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Expression of cytoskeleton genes in culture of human mesenchymal stromal cells in different periods of simulating the effects of microgravity

Gershkovich, P.M.; Gershkovich, I.G.; Buravkova, L.B.

Aviakosmicheskaia i Ekologicheskaia Meditsina 45(4): 39-41

2011

ISSN/ISBN: 0233-528X
PMID: 21970042
Document Number: 649800
Simulation of microgravity for cultivated multipotent mesenchymal stromal cells (MSCs) from human marrow changes transiently expression of genes associated with actin cytoskeleton; the effect fades away partially in 120 hrs. following microgravity and completely after 24-hr cell readaptation to static conditions. These changes in expression of some cytoskeleton genes seem to predetermine their reaction to simulated microgravity, and therefore inhibition of MSCs differentiation potential.

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