Mesenchymal stromal cells transplantation in acute and chronic pancreatitis in rats
Lazebnik, L.B.; Trubitsyna, I.E.; Agafonov, M.A.; Kniazev, O.V.; Liundup, A.V.
Eksperimental'naia i Klinicheskaia Gastroenterologiia 7: 28-31
2011
ISSN/ISBN: 1682-8658 PMID: 22363996 Document Number: 648791
Before using MSC transplantation in the clinic to conduct preclinical studies MSCs to animals with acute and chronic pancreatitis. Work out the timing and dose of MSCs. The rationale of MSCs transplantation for the regeneration of damaged pancreatic tissue. The essence of the experiments is to establish the existence of common pathogenetic mechanisms for the development of pathological processes and sanogenesis toxic damage of pancreatic tissue. The study was work out in the rat model of acute and chronic pancreatitis, to explore beneficial and adverse effects of allogeneic stem cells for regenerative-reduction processes. For cell transplantation using allogenic stromal cell fraction of bone marrow, the cell suspension was injected at a dose of 2 x 10(6) and 5 x 10(6) cells.