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Expression of metanephric differentiation markers in human mesenchymal stem cells

Bianchi, F.; La Manna, G.; Cantoni, S.; Cavallini, C.; Scolari, M.; Ventura, C.; Stefoni, S.

Giornale Italiano di Nefrologia Organo Ufficiale Della Societa Italiana di Nefrologia 26(Suppl 45): S64-S68

2009

ISSN/ISBN: 0393-5590
PMID: 19382097
Document Number: 637501
Stem cells are a potential source for the regeneration of many tissues, including damaged kidneys. The present study describes the adoption of hyaluronic- butyric acid monoesters (HB) to induce expression of nephrogenic genes by mesenchymal cells isolated from human placental membranes. HB at a concentration of 1 mg/mL induces chromatin opening and increases the expression of the observed markers (cadherin 11, CD24, RAR-alpha, stearoyl-CoA desaturase 2, 14-3-3 0, Ewing sarcoma homolog.). These results open new routes toward cell regeneration after kidney injury.

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