Formulation aspects and ex-vivo examination of buccal drug delivery systems
Szabó, B.ás.; Hetényi, G.; Majoros, K.; Miszori, V.; Kállai, N.; Zelkó, R.án.
Acta Pharmaceutica Hungarica 81(4): 165-172
2011
ISSN/ISBN: 0001-6659 PMID: 22329303 Document Number: 649036
Application of buccal dosage forms has several advantages. Buccal route can be used for systemic delivery because the mucosa has a rich blood supply and it is relatively permeable. This route of drug delivery is of special advantages, including the bypass of first pass effect and the avoidance of presystemic elimination within the GIT. Buccal delivery systems enable the systemic delivery of peptides and proteins. In our previous study the physiological background of this application and the excipients of the possible formulations were reviewed. In the present work the formulation and ex vivo examination aspects of buccal drug delivery systems are summarized.