It's in the bag: drug absorption by drug-delivery systems
Shader, R.I.; Greenblatt, D.J.
Journal of Clinical Psychopharmacology 17(5): 339-340
1997
ISSN/ISBN: 0271-0749 PMID: 9315983 Document Number: 7047
Twenty years ago, we and others conducting pharmacoldnetic studies or therapeutic plasmα-level monitoring became aware that the rubber stoppers in MonojectTM brand syringes contained an electron-capturing substance which leached out into the plasma and, by producing a peak at a retention time close to that of oxazepam, confounded determinations of the plasma levels of oxazepam itself or of lorazepam or any other drug when oxazepam was used as the internal standard.' The substance was never identified, and the manufacturer never acknowledged that the contaminant existed. Thereafter, we used other contaminant-free brands of syringes for pharmacokinetic studies.
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