Drug delivery systems for cancer chemotherapy
Inoue, K.
Nihon Geka Gakkai Zasshi 103(2): 224-228
2002
ISSN/ISBN: 0301-4894 PMID: 11904984 Document Number: 6589
Various types of drug delivery system (DDS) for antitumor drugs have been developed to reduce severe systemic toxicities and to enhance antitumor effects by improving their pharmacokinetics. In this paper, outlines are first given of the concept and design of DDS, focusing on polymeric antitumor drugs (macromolecular prodrugs) and then describing the superior DDS effects shown in preclinical studies of DE-310, a DDS optimized for the camptothecin analogue DX-8951. Clinical trials of DE-310 are now ongoing in the USA and Europe.
Document emailed within 1 workday
