Novel biodegradable materials for drug delivery systems (DDS)
Sugitachi, A.; Kashiwaba, M.; Shimada, Y.; Terashima, M.; Asahi, H.; Saitoh, K.; Yoshida, Y.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 28(11): 1530-1533
2001
ISSN/ISBN: 0385-0684 PMID: 11707972 Document Number: 536834
The authors provide three new and different types of fibrin gels (FCs) and a chitosan sheet (BC) using an ultraviolet (UV)-crosslinking method. They are 1) FC-UV, 2) gelatin entrapped FC; FC (Gp)-UV, 3) chitosan entrapped FC; FC (Cs)-UV and 4) BC-UV. Each material was loaded with aqueous cis-platinum (CDDP), and both the degradation of the drug carriers and the release profile of the CDDP were examined in vitro. The FCs, 1)-3), gradually degraded and dissolved within 10-12 days. The BC, 4), maintained its original weight for more than 30 days. Each FC showed a sustained release of CDDP for 10 days, while BC provided an initial bursting of the loaded drug. New materials 2) and 3) show great potential as drug carriers for DDS and further in vivo studies are now proceeding.