Oral premedication with midasolam and ketamine in children with neurosurgical diseases
Kulikov, A.S.; Sorokin, V.S.; Lubnin, A.I.
Anesteziologiia i Reanimatologiia 1: 6-10
2010
ISSN/ISBN: 0201-7563 PMID: 20564930 Document Number: 641729
The study was undertaken to evaluate the efficiency and safety of oral premedication in children with intracranial neurosurgical pathology before elective interventions in two modalities: a combination of midasolam 0.5 mg/kg body weight and ketamine 3 mg/kg (Group 1; n = 80) and midasolam 0.75 mg/kg only (Group 2; n = 20). The study was conducted in 100 children aged 2 to 10 years. Medical and sweet syrups were used to dilute the agents. In Groups 1 and 2, an effective anxiolytic effect was achieved in 92 and 80%, respectively. A sedative effect was also more pronounced in Group 1 children. The mean duration of effect achievement was 20 minutes. There were no serious complications when both regimens were used. Both oral premedication modes are considered to be effective and must be used for premedication in children with neurosurgical diseases.