Study of midazolam for premedication in oral and maxillofacial surgery
Jiang, H.; Zhu, Y.; Wang, X.; Zhu, Y.-s.
Shanghai Kou Qiang Yi Xue 12(3): 170-173
2003
ISSN/ISBN: 1006-7248 PMID: 14661322 Document Number: 563349
To study the effects of midazolam for premedication in oral-maxillofacial surgery. 60 patients were selected and divided into 3 groups equally with 20 cases in each group. Different drugs were used for premedication. Group received midazolam 0.06 mg/kg, group received diazepam 0.12 mg/kg, group received luminal 3 mg/kg, Intramuscular injections of drugs were finished before 30 minutes of anesthesia. The sedative and anxiolytic effects, the changes of circulation and respiration and the side effects were evaluated. In group, BIS (bispectral analysis of electroencephalogram) decreased obviously and Ramsay score increased significantly 5 minutes after drug administration, AVAT(Anxiety visual analog test) and SAI(State anxiety inventory) decreased obviously 30 minutes after administration drug (P < 0.05). But no significant changes in the other groups (P > 0.05). There were no remarkable changes of circulation and respiration in the three groups. No severe side effects were observed after premedication. The premedication of using midazolam has good sedative and anxiolytic effects and few side effects.