Oral benzodiazepine premedication in minor gynaecological surgery
Male, C.G.; Johnson, H.D.
British Journal of Anaesthesia 56(5): 499-507
1984
ISSN/ISBN: 0007-0912 PMID: 6144317 Document Number: 224837
Clobazam 20 mg, diazepam 10 mg, lorazepam 2 mg and oxazepam 30 mg were compared in a randomized, double-blind, placebo-controlled trial as oral premedication for 150 patients undergoing minor gynecological surgery. All drugs and placebo significantly decreased anxiety when assessed by the patient on a 10-cm linear analog rating scale 60 min after premedication. Diazepam 10 mg induced significantly more drowsiness when assessed by a trained observer 60 min after premedication than clobazam 20 mg, oxazepam 30 mg and placebo (P < 0.01). Lorazepam 2 mg caused significantly more drowsiness 2 h (P < 0.001) and 4 h (P < 0.01) after operation, and significantly impaired psychomotor function after operation compared with the other 4 agents. Evidently, clobazam 20 mg, diazepam 10 mg, oxazepam 30 mg or placebo offer advantages over lorazepam 2 mg for oral premedication in minor gynecological surgery where early discharge after operation is preferred.