Allotransplantation of Leydig cells increases serum testosterone in rats
Sun, J.; Shi, C.-R.; Xi, Y.-B.; Li, W.-Y.; Li, H.-Y.
Zhonghua Nan Ke Xue 14(9): 823-825
2008
ISSN/ISBN: 1009-3591 PMID: 18998468 Document Number: 618034
To observe the changes of serum testosterone after allotransplantation of Leydig cells in rats. Leydig cells were isolated from the testes of SD rats with the Percoll technique and serum testosterone of the receptors was determined once a month for 3 successive times. After allotransplantation of Leydig cells, the serum testosterone level of the receptors increased gradually, significantly higher at 3 months than that of the normal rats younger than 2 months old. Allotransplantation of Leydig cells has a promising application value in the treatment of male primary hypogonadism.