Synthesis and antimycobacterial activity of selected nitrobenzyloxylated benzotriazoles
Augustynowicz-Kopeć, E.; Zwolska, Z.; Orzeszko, A.; Kazimierczuk, Z.
Acta Poloniae Pharmaceutica 65(4): 435-439
2008
ISSN/ISBN: 0001-6837 PMID: 19051584 Document Number: 616271
A series of 1-nitrobenzyloxybenzotriazoles was prepared by the benzylation of the respective halogenosubstituted 1-hydroxybenzotriazoles. The newly obtained compounds were tested against four Mycobacterium strains. Particularly high antimycobacterial activity, comparable with that of isoniazide, was found for 5,6-dichloro- 1-(3,5-dinitrobenzyloxy)- 1H-benzotriazole.
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