Case of clear cell hidradenoma with mucinous metaplasia in the forehead--immunohistochemical analysis of the mucin
Ishida, M.; Kojima, F.; Kushima, R.; Kakutani, A.; Okabe, H.
Rinsho Byori. Japanese Journal of Clinical Pathology 54(8): 781-784
2006
ISSN/ISBN: 0047-1860 PMID: 16989395 Document Number: 601110
Mucinous metaplasia rarely develops in the non-neoplastic skin or its appendages, and almost exclusively confined to the genitalia, palms and soles. Similarly, mucinous metaplasia is quite uncommon in the cutaneous neoplasms and only few cases of clear cell hidradenomas and squamous cell carcinomas with mucinous metaplasia have been reported in the literature. Here we report a new case of clear cell hidradenoma with mucinous metaplasia in the forehead. Our immunohistochemical analysis revealed MUC5AC in the mucinous metaplastic cells of this tumor as in the extramammary Paget's disease, and expression of this gastric foveolar epithelial mucin core protein in these two neoplastic conditions seem to related to their common apocrine origin.