Analysis of survival rates in patients and prognostic models in non-metastatic clear-cell renal cell carcinoma
Iurin, A.G.; Koval'skiĭ, G.B.
Arkhiv Patologii 71(6): 15-20
2009
ISSN/ISBN: 0004-1955 PMID: 20131500 Document Number: 634770
The Cox multivariate regression analysis of survival rates in patients with non-metastatic clear-cell renal cell carcinoma, by taking into account both various clinical, anatomic, morphometric, and biomolecular factors and kariometric parameters, has revealed that Ki-67 and p53 expression rates along with histologic grade, a tumor portion made up of clear-cell components, and the presence/absence of tumor invasion into paranephral fat tissue are independent prognostic predictors of the disease. By applying the proposed three prognostic models (algorithms) using Ki-67 and p53 expression rates for predicting the corrected survival rates for patients with non-metastatic clear-cell renal cell carcinoma, the authors suggest that a combined biomolecular-morphometric model is of the greatest prognostic value.