Survival and prognostic factors in renal cell carcinoma in Saudi patients: A ten year review
Talic, R.F.; El Faqih, S.R.
Saudi Medical Journal 19(2): 170-173
1998
ISSN/ISBN: 0379-5284 PMID: 27701580 Document Number: 486407
Objectives: To study the survival pattern and prognostic variables that influence the management outcome of Saudi patients with renal cell carcinoma (RCC). Patients and methods: A retrospective review of 32 Saudi patients with renal cell carcinoma was carried out. Kaplan-Meier curves were used for survival analysis. Age, sex, clinical presentation and pathological features of the tumors were analyzed for their significance as prognostic factors using the multivariate analysis by Cox proportional hazard model. Results: The group comprised 18 male and 14 female patients with a mean age 50.9 +- 14.5 years. Patients with stage I, II and III(a) disease had a 5 year survival of 95% in comparison to 15% for stage IV disease; this marked difference in survival was statistically significant (p=0.0001). The survival was also significantly different according to tumor size (p=0.005); the 5 year survival was 95% for patients with tumors less than 10 cm in size compared to 25% for patients with tumors greater than 10 cm. Two important and independent prognostic variables were noted using the Cox proportional hazard model: the anatomic extent of the tumor (p=0.02) and the tumor size (p=0.033). Conclusion: Our study affirms that the stage of RCC at presentation is the most important prognostic factor affecting the survival of patients. Size of the tumor was also important and independent prognostic variable.