Immunohistochemical staining of mucin 1 in prostate tissues
Rabiau, N.; Dechelotte, P.; Guy, L.; Satih, S.; Bosviel, R.; Fontana, L.; Kemeny, J.-L.; Boiteux, J.-P.; Bignon, Y.-J.; Bernard-Gallon, D.
In Vivo 23(2): 203-207
2009
ISSN/ISBN: 0258-851X PMID: 19414404 Document Number: 631510
Prostate cancer is a major public health problem in the world. Molecular studies are necessary for the development of prognostic markers in prostate cancer. There is a great interest in mucin studies in treatment development of human malignancies, including prostate cancer. Nevertheless, their expressions in prostate cancer need further investigation. Mucin 1 (MUC1) expression was examined in 100 prostate biopsies and were compared with prostate carcinoma cell lines (DU-145, PC-3, LNCaP) by immunohistochemistry. Biopsies were healthy, tumor, peritumor or presented an intraepithelial neoplasia. Staining of MUC1 was exihibited in PC-3 cells, was higher in DU-145, and was not expressed by LNCaP. Tumor sections presented more positive expression of MUC1 than non-tumor sections. MUC1 expression is correlated with the histological degree of malignancy.