Proliferative and mucin-producing activities in the foci of intestinal metaplasia associated with chronic atrophic gastritis and gastric ulcer
Mozgovoĭ, S.I.; Livzan, M.A.; Predvechnaia, I.K.; Kononov, A.V.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 7: 15-18
2010
ISSN/ISBN: 0869-6047 PMID: 20795397 Document Number: 644322
Immunohistochemical studies revealed the dependence of cell regeneration parameters at sites of intestinal metaplasia (IM) in gastric mucosa (GM) on the character of the background events, such as atrophy and erosive-ulcerative defect. Mucin profile was determined in various types of IM. The intestinal type of mucin was found only in type I IM while types II and III were characterized by the mixed gastrointestinal phenotype with expression MUCSAC and MUC2. It was shown that at sites of incomplete IM (types II and III) and atrophic changes of GM cells proliferation activity of epithelium is considerably increased; this increase may be associated with the risk of developing gastric cancer of the intestinal type.