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Synthesis and characteristics of the fluorouracil-dextran conjugates

Hao, A.Jun.; Deng, Y.Jie.; Suo, X.Bin.; Cao, Y.Hong.

Die Pharmazie 61(5): 489-490

2006

ISSN/ISBN: 0031-7144
PMID: 16724554
Document Number: 596164
Fluorouracil acetic acid (FUAC) was first chemically bound to dextran in a solvent mixture (FA/DMF/ DCM = 10: 9: 1, v/v/v) catalyzed by DMAP and DCC. The conjugate obtained was confirmed by analysis of UV, IR and NMR spectra. The degree of substitution (DS) of the conjugates was dependent on the proportions of FUAC and dextran used in the reaction mixture. Investigation of the chemical stability revealed that the conjugate was stable in an acidic buffer solution. The conjugate will find application in drug targeting and controlled release.

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