Comparative effects of Aegle marmelos extract and alpha-tocopherol on serum lipids, lipid peroxides and cardiac enzyme levels in rats with isoproterenol-induced myocardial infarction
Rajadurai, M.; Prince, P.S.M.
Singapore Medical Journal 46(2): 78-81
2005
ISSN/ISBN: 0037-5675 PMID: 15678289 Document Number: 594806
Introduction: We demonstrate the effect of Aegle marmelos leaf extract (AMLEt) and alpha-tocopherol on plasma lipids, lipid peroxides and marker enzymes in rats with isoproterenol (ISO)-induced myocardial infarction. Methods: Rats were pre-treated orally for 35 days with different doses of an aqueous AMLEt (50, 100 and 200 mg/kg) prior to ISO-induced myocardial infarction. The effects on creatine kinase, lactate dehydrogenase, plasma thiobarbituric acid reactive substances, lipid hydroperoxides, serum lipids and lipoproteins were studied. Results: Pre-treatment with AMLEt at doses of 100 mg/kg and 200 mg/kg body weight for 35 days showed a significant effect on the activities of marker enzymes, lipid peroxides, lipids, lipoproteins and antioxidant enzymes in ISO-treated rats. The effect of AMLEt 200 mg/kg was found to be equal to the effect of alpha-tocopherol 60 mg/kg. Conclusion: A. marmelos leaves possess antihyperlipidaemic effect in rats with ISO-induced myocardial infarction.