Effects of cadmium on lipid peroxides and superoxide dismutase in hepatic, renal and testicular tissue of rats
Patra, R.C.; Swarup, D.; Senapati, S.K.
Veterinary and Human Toxicology 41(2): 65-67
1999
ISSN/ISBN: 0145-6296 PMID: 10192131 Document Number: 503666
Daily i.p. administration of 0.5 mg cadmium (Cd)/kg body weight to rats for 3 mo enhanced lipid peroxidation and inhibited superoxide dismutase (SOD) activity in liver, kidney and testes. Accumulation of Cd and SOD inhibition was maximum in liver followed by kidney and testes, indicating a direct effect of Cd on SOD activity. This suggests a role of free radicals in causing cellular damage with long-term exposure to cadmium.
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