Pharmacokinetics and distribution of superoxide dismutase liposomes in rats
Zhang, Y-long.; Xie, Y.; Wang, H-juan.; Hou, X-pu.; Liu, Y.
Yao Xue Xue Bao 40(2): 173-177
2005
ISSN/ISBN: 0513-4870 PMID: 15875677 Document Number: 591699
Aim To evaluate the effects of surfactants on the pharmacokinetics and distribution in rats after intravenous administration of SOD liposomes. Methods The liposomes were prepared by reverse phase evaporation method. The activity of SOD was assayed by method of xanthine oxidase. Results The T-1/2 of SOD solution, common SOD liposome, SOD liposomes modified by DSPE-PEG2000 and Tween 80 were 0.25, 0.34, 0.66 and 0.41 h, respectively; AUC were 12.48, 24.66, 41.16 and 33.02 mu g . h . mL(-1), respectively. Compared with the common liposome, the liposomes modified by DSPE-PEG and Tween 80 decreased the content of SOD in liver and spleen, but increased in brain. Conclusion The three kinds of liposomes could increase T-1/2 and AUC in some extent, especially in PEG-L group. Tween-L could increase the SOD content in brain, and PEG-L could decrease the SOD content in the liver and spleen compared with the common liposome.