Lipid peroxides and atherosclerosis. the enzymatic detoxication of lipid peroxides in the blood in ischemic heart disease due to coronary artery arteriosclerosis
Lankin, V.Z.; Gerasimova, E.N.; Kasatkina, L.V.; Tikhaze, A.K.; Suchkova, S.N.
Kardiologiia 19(6): 71-76
1979
ISSN/ISBN: 0022-9040 PMID: 459235 Document Number: 152196
It was established that in blood of patients with ischemic heart disease due to atherosclerosis of the coronary arteries (the diagnosis was verified in selective coronaroangiography) the content of acylhydroperoxides grows while the activity of glutathione-peroxidase II decreases. In blood of patients with no damage to the coronary vessels (according to the results of angiography), glutathione-peroxidase II activity does not differ significantly from the values in the control group. The decrease of glutathione-peroxidase II activity was most marked in patients with ischemic heart disease and hypercholesterolemia. It is suggested that the increase in the peroxide content in blood of patients with ischemic heart disease may be due to the sharp decrease in the activity of glutathione-peroxidase II.