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Protective effects of ligustrazine against photoreceptor cell injury induced by N-methyl-N-nitrosourea and its mechanism

Yang, J-nan.; Xu, J-gong.; Chen, J-mao.; Lin, S-chun.; Luo, L.; Hu, S-xing.

Yao Xue Xue Bao 40(8): 690-694

2005

ISSN/ISBN: 0513-4870
PMID: 16268501
Document Number: 594234
Aim: To study the protective effect of ligustrazine technique. Results: Ligustrazine injection remarkably increased the total thickness of peripheral retina and decreased the apoptotic index of photoreceptor cells induced by MNU in a dose-dependent manner. Compared with MNU-treated rats, the expression of c-jun and c-fos was time-dependently downregulated in ligustrazine-treated group. Conclusion: Ligustrazine injection partially protects against MNU-induced retinal damage by down-modulating the expression of c-jun and c-fos genes to inhibit apoptosis of photoreceptor cells.

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